Active Purified Enzymes
NOVOCIB produces active nucleoside kinases and other nucleotide metabolism enzymes. This portfolio of enzymes represents a unique range of powerful tools for Drug Discovery and research in the field of nucleoside and nucleotide metabolism.Purine Metabolism Enzymes
| IMPDH | Inosine Monophosphate Dehydrogenase (EC 1.1.1.205) | Human Type II, recombinant, expressed in E.coli
Bacterial (Staphylococcus aureus) recombinant, expressed in E.coli |
| PNP | Purine Nucleoside Phosphorylase (EC 2.4.2.1) | Human recombinant, expressed in E.coli |
| XDH | Xanthine Dehydrogenase (EC 1.17.1.4) | Native enzyme, extracted from bovine milk |
| HGPRT | Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) |
Human recombinant, expressed in E.coli |
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Nucleoside Kinases
| ADK | Adenosine Kinase (EC 2.7.1.20) | Human, recombinant, expressed in E.coli |
| dCK | Deoxycytidine Kinase (EC 2.7.1.74) | Human recombinant, expressed in E.coli |
| CMK | UMP-CMP Kinase (EC 2.7.4.14) | Human recombinant, expressed in E.coli |
| cN-II | Cytosolic 5'-nucleotidase II (EC 3.1.3.5) | Human recombinant, expressed in E.coli |
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Bacterial Bioluminescence Enzymes
| Bacterial Luciferase | (EC 1.14.14.3) | Bacterial, produced from a selected strain of Photobacterium phosphoreum |
| FMN Reductase | (EC 1.5.1.29) | Bacterial recombinant, E.coli |
Bacterial bioluminescence consists in a ligh-emitting reaction where a long-chain aliphatic aldehyde is oxidized in the presence of molecular oxygen and reduced flavin mononucleotide (FMNH2). This reaction is catalyzed by bacterial luciferase.
NOVOCIB offers a highly pure bacterial luciferase from Photobacterium phosphoreum and a recombinant FMN-Reductase which, when coupled to bacterial luciferase in vitro, is able to significantly increase the sensitivity and allow a better control of signal intensity and duration.
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Please, contact us for any questions.